Merlin Rabbit pAb - A22558

Merlin Rabbit pAb

Sizes: 20μL, 100μL

Catalogue Numbers: A22558-20, A22558-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.

Category: Polyclonal Antibodies

Applications: WB, ELISA

Cross-reactivity: Human, Mouse, Rat

Protein Weight: 70kDa

Observed Molecular Weight: 75kDa

Immunogen: Recombinant protein (or fragment) .

Species: Human

GeneID: 4771

SWISS: P35240

Alternate Names: ACN; SCH; BANF; merlin-1; Merlin

Source: Rabbit

Isotype: IgG

Purity: Affinity purification

Storage: Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis),  pH 7.3.

Recommended Dilutions: WB, 1:500 - 1:1000 ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Research Areas: Epigenetics Nuclear Signaling, Protein phosphorylation, Cancer, Tumor suppressors, Signal Transduction, Cell Biology Developmental Biology, Cell Adhesion, Neuroscience.

NCBI Alias: NF2

Research Use Only