MerTK Rabbit Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS9846M-50, BS9846M-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q12866
Host: Rabbit
Reactivity: Human
Applications: WB, IHC, IP,
All Applications: WB: 1:1000-1:2000
IHC: 1:50-1:200
Background: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulin-like C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol- specific phospholipase C γ2 (PI-PLC γ2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.
Purification and Purity: Protein A affinity purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This antibody detects endogenous levels of MerTK and does not cross-react with related proteins.
Bioworld Molecular Weight: ~ 110, 180 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of MerTK Rabbit mAb at 1:1000 dilution
Lane 1: 293 whole cell lysate, Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MerTK antibody. Counter stained with hematoxylin.
Alternative Name: Tyrosine-protein kinase Mer; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK; MERTK; MER
Immunogen: Recombinant antibody.
Conjugate: Unconjugated
Modification: Unmodified