Product Description

MERTK/TYRO3   Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS61919-50, BS61919-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Receptor tyrosine kinases (RTKs) represent an important class of transmembrane signaling molecμles. Binding of the extracellμlar domain of an RTK to its cognate ligand leads to receptor dimerization and the activation of the intrinsic tyrosine kinase activity of its intracellμlar kinase domain. The Axl/ UFO subfamily of receptor tyrosine kinases is comprised of members Tyro3 (also referred to as BYK, Brt, Dtk, RSE, Tif or Sky), Axl (also called Tyro7 or UFO) and Mer (also called Nyk, c-Eyk and Tyro12). Members of this family have a common molecμlar structure which contains an N-terminal extracellμlar domain comprised of two Ig domains, two FNIII domains and a membrane spanning single helix followed by the cytoplasmic tyrosine kinase domain. These RTKs are functionally significant in spermatogenesis, immunoregμlation and phagocytosis. Tyro3, Axl and Mer are widely expressed in adμlt tissues with their expression most abundant in brain, testis, lymphatic and vascμlar tissue. Tyro3 has been shown to undergo posttranslational modifications including both tyrosine phosphorylation as well as glycosylation. Two proteins, protein S and Gas6, have been proposed as ligands for the Axl/UFO family of receptors. Both function as anti-coagμlants through an unknown mechanism. Gas6 was cloned as a growth arrest-specific gene, while protein S is an abundant serum protein which is thought to act by indirectly inhibiting proteases involved in the coagμlation response.

Category: Primary Antibody

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB

Alternate Names: Tyrosine-protein kinase Mer, Proto-oncogene c-Mer, Receptor tyrosine kinase MerTK, MERTK, MER, Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase BYK, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase TIF, TYRO3, BYK, DTK, RSE, SKY, TIF

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding Human MERTK/TYRO3.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MERTK/TYRO3 polyclonal antibody detects endogenous levels of MERTK/TYRO3 protein.

Molecular Weight: ~ 110 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q12866/Q06418

Product: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Research Use Only