Met Rabbit Polyclonal Antibody - RA30798

Met Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA30798-50, RA30798-100

Citations, Manuals and MSDS Available upon request.

Background: MET proto-oncogene, receptor tyrosine kinase (MET) Homo sapiens This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC 1:100-200

Alternative Names: MET; YM3679

Applications: IHC-p; IF (paraffin section)

Species Cross-Reactivity: Human; Rat; Mouse

GeneID (Human): 4233

Protein MW (KDa): 140170

SWISS: P08581

Source: Rabbit

Research Use Only