Product Description

Metadherin Monoclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: MB66636-50, MB66636-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Lyric/AEG-1 (Astrocyte Elevated Gene 1)/MTDH (Metadherin) was identified as a tight junction (TJ) protein based on its localization to TJ proteins in polarized epithelium. Differential subcellμlar localization and overexpression of Lyric/AEG-1/MTDH has been seen in mμltiple human cancers. Lyric/AEG-1/MTDH is involved in signaling pathways related to various cellμlar functions including proliferation and apoptosis/survival, and its alteration in cancer is associated with poor prognosis. In breast cancer, increased Lyric/AEG-1/MTDH may confer increased chemoresistance as well as metastasis. Lyric/AEG-1/MTDH expression is important in signaling and disease progression of hepatocellμlar carcinoma (HCC) and glioblastoma mμltiforme (GBM).

Category: Primary Antibody

Reactivity: Human

Host: Mouse

Applications: WB, IHC, FC

Alternate Names: AEG1, LYRIC, Protein LYRIC, 3D3/LYRIC, Astrocyte elevated gene-1 protein, AEG-1, Lysine-rich CEACAM1 co-isolated protein, Metadherin, Metastasis adhesion protein

Clonality: Monoclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Purified recombinant fragment of human Metadherin expressed in E. Coli.

Dilution: WB (1/500 - 1/1000), IHC (1/50 - 1/100), FC (1/50 - 1/100)

Purification: The antibody was purified by immunogen affinity chromatography.

Specificity: Recognizes endogenous levels of Metadherin protein.

Molecular Weight: ~ 60 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q86UE4

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Research Use Only