Product Description

Mfn2 (F403) Polyclonal Antibody

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Catalogue Numbers: BS3682-50, BS3682-100

Sizes: 50µl, 100µl

Swiss-Prot: O95140

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

Background: MFN2 is an essential transmembrane GTPase which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton, plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 lead to Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system.

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Mfn2 (F403) polyclonal antibody detects endogenous levels of Mfn2 protein.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Mfn2 (F403) pAb in paraffin-embedded human lung carcinoma tissue.

Bioworld Molecular Weight: ~ 86 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Alternative Name: Mitofusin-2; Transmembrane GTPase MFN2; CPRP1; KIAA0214; MFN2;

Immunogen: Synthetic peptide, corresponding to amino acids 381-430 of Human Mfn2.

Conjugate: Unconjugated

Modification: Unmodified