Mfn2 rabbit pAb - ES2784

Mfn2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES2784-50, ES2784-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],

Alternate Name: MFN2; CPRP1; KIAA0214; Mitofusin-2; Transmembrane GTPase MFN2

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. IF 1:100-300 Not yet tested in other applications.

Reactivity: Human; Mouse; Rat

Immunogen: The antiserum was produced against synthesized peptide derived from human Mfn2. AA range:354-403

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 86kD

Human Gene ID: 9927

Human SWISS Prot NO: O95140

Subcellular Location: Mitochondrion outer membrane; Multi-pass membrane protein. Colocalizes with BAX during apoptosis.

Research Use Only