mGluR-6 rabbit pAb - ES5678

mGluR-6 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5678-50, ES5678-100

Citations, Manuals and MSDS Available upon request.

Background: glutamate metabotropic receptor 6 (GRM6) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Feb 2012],

Alternate Name: GRM6; GPRC1F; MGLUR6; Metabotropic glutamate receptor 6; mGluR6

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human mGluR6. AA range:828-877

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 100kD

Human Gene ID: 2916

Human SWISS Prot NO: O15303

Subcellular Location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cell projection, dendrite. Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane.

Research Use Only