Product Description

mGluR2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90852-50, BS90852-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14416(Human) Q14BI2(Mouse) P31421(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC/IF, IHC

All Applications: WB:1:1,000
ICC:1:50-1:200
IHC:1:50-1:200

Background: The mGluR proteins (metabotropic glutamate receptors) are members of the G-protein-coupled receptor family and are functionally and pharmacologically distinct from the GluR proteins (ionotropic glutamate receptors). The eight currently known mGluR proteins are mediated by two G-proteins with opposing regulation of adenylate cyclase pathways. The activities of mGluR1 and mGluR5 are mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The remainder of the eight sub-types of mGluR have an activity mediated by a G-protein that inhibits adenylate cyclase activity. mGluR-2, which may interact with GRASP, acts as a receptor for glutamate. It may also be involved in the regulation of neurotransmission suppression and in synaptogenesis or synaptic stablization.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: mGluR2 polyclonal antibody detects endogenous levels of mGluR2 protein.

Bioworld Molecular Weight: 96 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining mGluR2 in SH-SY-5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining mGluR2 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: mGluR2, GRM2, AMPA selective glutamate receptor 2, GLUR2, GLURB, Glutamate metabotropic receptor 2, Glutamate receptor homolog, Glutamate receptor metabotropic 2, GPRC1B, GRM2, GRM2, Metabotropic glutamate receptor 2, mGlu2, mGluR2, OTTHUMP00000210984, OTTHUMP00000210986,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified