MGMT Polyclonal Antibody - BT-AP05395

MGMT Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP05395-20, BT-AP05395-50, BT-AP05395-100

Citations, Manuals and MSDS Available upon request.

Background: Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. Methylated-DNA--protein-cysteine methyltransferase encoded by MGMT is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. Methylated-DNA--protein-cysteine methyltransferase catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: MGMT

Applications: WB, IHC-p, ELISA

Reactivity: Human, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: MGMT Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 21646

UniProt Accession: Human: P16455; Mouse: P26187; Rat: P24528

Synonyms: MGMT; Methylated-DNA--protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase

GeneID: Human: 4255; Rat: 25332

Research Use Only