MIB2 Polyclonal Antibody - BT-AP11327

MIB2 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11327-20, BT-AP11327-50, BT-AP11327-100

Citations, Manuals and MSDS Available upon request.

Background: E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.,induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated. Possibly via autoubiquitination.,Contains 1 ZZ-type zinc finger.,Contains 2 MIB/HERC2 domains.,Contains 2 RING-type zinc fingers.,Contains 9 ANK repeats.,subcellular location:Colocalizes with endosomal compartments.,subunit:Interacts with actin monomer.,tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,

Research Areas: Signal transduction

Target Protein: MIB2

Applications: WB, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: E3 ubiquitin-protein ligase MIB2

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q96AX9; Mouse: Q8R516; Rat: Q68LP1

Synonyms: E3 ubiquitin-protein ligase MIB2;EC 6.3.2.-;Mind bomb homolog 2;Novel zinc finger protein;Novelzin;Putative NF-kappa-B-activating protein 002N;Skeletrophin;Zinc finger ZZ type with ankyri

GeneID: Human: 142678

Research Use Only