MIB2 rabbit pAb - ES10756

MIB2 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES10756-50, ES10756-100

Citations, Manuals and MSDS Available upon request.

Background: function:E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors., induction:Down-regulated in many primary skin melanomas. Treatment with a demethylating agent, 5'-aza-2-deoxycytidine, restores expression, suggesting that down-regulation is the result of methylation of the gene., pathway:Protein modification; protein ubiquitination., PTM:Ubiquitinated. Possibly via autoubiquitination., similarity:Contains 1 ZZ-type zinc finger., similarity:Contains 2 MIB/HERC2 domains., similarity:Contains 2 RING-type zinc fingers., similarity:Contains 9 ANK repeats., subcellular location:Colocalizes with endosomal compartments., subunit:Interacts with actin monomer., tissue specificity:Expressed in skeletal muscle, and to a lesser extent in heart, brain and kidney.,

Source: Rabbit

Applications: WB; ELISA

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Reactivity: Human; Mouse; Rat

Immunogen: Synthesized peptide derived from part region of human protein

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 111kD

Human Gene ID: 142678

Human SWISS Prot NO: Q96AX9

Subcellular Location: Cytoplasm. Endosome. Colocalizes with endosomal compartments.

Research Use Only