Product Description

Midkine Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90858-50, BS90858-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P21741(Human)

Host: Rabbit

Reactivity: Human

Applications: WB, IHC, IP,

All Applications: WB:1:500-1:1,000
IHC:1:50-1:200

Background: Midkine, or MK, is a heparin-binding molecule involved in the regulation of growth and differentiation during embryogenesis. MK expression is tightly regulated during embryonic development by steroid receptors of the retinoic acid superfamily. The mature human MK protein is 118 amino acids in length and contains five intrachain disulfide bonds. MK is a non-glycosylated protein that shows greater than 87% identity between human and mouse. The carboxy-terminus of MK contains the principle heparin-binding site and the molecule’s neurite-promoting sequences; both the amino- and carboxy-terminal sequences are required for the molecule’s neurotrophic properties. An association between overexpression of MK and colon adenocarcinoma has been shown in families suffering from familial polyposis. In addition, MK functions to enhance the activity of plasminogen activator (PA).

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Midkine polyclonal antibody detects endogenous levels of Midkine protein.

Bioworld Molecular Weight: 16 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemical analysis of paraffin-embedded human liver cancer tissue using anti-Midkine antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded human pancreas tissue using anti-Midkine antibody. Counter stained with hematoxylin.

Alternative Name: MK, ARAP, MDK, Amphiregulin associated protein, Amphiregulin-associated protein, ARAP, FLJ27379, Mdk, Midgestation and kidney protein, Midkine, MK 1, MK, MK, MK1, NEGF 2, NEGF2, Neurite growth promoting factor 2, Neurite outgrowth promoting protein, Neurite outgrowth-promoting factor 2, Neurite outgrowth-promoting protein, Retinoic acid inducible factor,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified