MLH3 rabbit pAb - ES5531

MLH3 rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES5531-50, ES5531-100

Citations, Manuals and MSDS Available upon request.

Background: This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008],

Alternate Name: MLH3; DNA mismatch repair protein Mlh3; MutL protein homolog 3

Source: Rabbit

Applications: WB; IHC; IF; ELISA

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Reactivity: Human; Rat; Mouse;

Immunogen: The antiserum was produced against synthesized peptide derived from human MLH3. AA range:521-570

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 164kD

Human Gene ID: 27030

Human SWISS Prot NO: Q9UHC1

Subcellular Location: Nucleus

Research Use Only