MLKL (phospho-S345) Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS94021-50, BS94021-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9D2Y4(Mouse)
Host: Rabbit
Reactivity: Mouse,
Applications: IHC
All Applications: IHC:1:50-1:100
Background: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: MLKL (phospho-S345) polyclonal antibody detects endogenous levels of MLKL protein only when phosphorylated at S345.
Bioworld Molecular Weight: 54 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti-MLKL (phospho S345) antibody. Counter stained with hematoxylin., Immunohistochemical analysis of paraffin-embedded mouse lung tissue using anti-MLKL (phospho S345) antibody. Counter stained with hematoxylin.
Alternative Name: Mlkl, 9130019I15Rik, FLJ34389, hMLKL, Mixed lineage kinase domain like, Mixed lineage kinase domain like protein, Mixed lineage kinase domain like pseudokinase, Mixed lineage kinase domain-like protein, Mlkl, MLKL,
Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser345 of human MLKL.
Conjugate: Unconjugated
Modification: Phosphorylation