Product Description

MLKL (phospho S358) Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA21416-50, RA21416-100

Citations, Manuals and MSDS Available upon request.

Background: mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: IHC-p 1:50-200, WB 1:500-2000

Alternative Names: Mixed lineage kinase domain-like protein

Applications: IHC-p; IF (paraffin section) ; WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 197259

Protein MW (KDa): 55

SWISS: Q8NB16

Source: Rabbit

Research Use Only