MLKL (phospho Ser358) rabbit pAb - ES14935

MLKL (phospho Ser358) rabbit pAb

Sizes: 50μL, 100μL

Catalogue Numbers: ES14935-50, ES14935-100

Citations, Manuals and MSDS Available upon request.

Background: This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Alternate Name: Mixed lineage kinase domain-like protein

Source: Rabbit

Applications: IHC; IF; WB

Dilution: IHC-p 1:100-500; IF/ICC 1:100-500; WB 1:500-2000

Reactivity: Human

Immunogen: Synthesized peptide derived from human MLKL (phospho S358)

Storage and Stability: -20°C/1 year

Clonality: Polyclonal

Isotype: IgG

Concentration: 1 mg/ml

Observed Band (KD): 55kD

Human Gene ID: 197259

Human SWISS Prot NO: Q8NB16

Subcellular Location: Cytoplasm. Cell membrane. Nucleus. Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671). Localizes to the nucleus in response to orthomyxoviruses infection (By similarity).

Research Use Only