MLKL Phospho-ser358 Rabbit Polyclonal Antibody - RA36821

MLKL Phospho-ser358 Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA36821-50, RA36821-100

Citations, Manuals and MSDS Available upon request.

Background: mixed lineage kinase domain like (MLKL) Homo sapiens This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

Condition: Liquid in PBS containing 50% glycerol, and 0.136% sodium azide.

Storage Instructions: -20°C/1 year

Recommended dilutions: WB 1:500-2000

Alternative Names: Mixed lineage kinase domain-like protein

Applications: WB

Species Cross-Reactivity: Human; Mouse; Rat

GeneID (Human): 197259

SWISS: Q8NB16

Source: Rabbit

Research Use Only