MLKL Rabbit Monoclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS9822M-50, BS9822M-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q8NB16
Host: Rabbit
Reactivity: Human
Applications: WB, IHC
All Applications: WB: 1:1000-1:5000
IHC: 1:50-1:200
Background: MLKL (mixed lineage kinase domain-like) is a 471 amino acid protein that contains one protein kinase domain which is thought to be catalytically inactive. The gene encoding MLKL maps to chromosome 16 and is expressed as two isoforms which are produced by alternative splicing events. Chromosome 16, which is associated with a variety of genetic disorders, encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
Purification and Purity: Protein A affinity purified
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This antibody detects endogenous levels of MLKL and does not cross-react with related proteins.
Bioworld Molecular Weight: ~ 54 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of MLKL Rabbit mAb at 1:1000 dilution
Lane 1: HT29 whole cell lysate
Lane 2: HUVEC whole cell lysate
Lane 3: Hela whole cell lysate, Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-MLKL antibody. Counter stained with hematoxylin
Alternative Name: Mixed lineage kinase domain-like protein
Immunogen: Recombinant antibody.
Conjugate: Unconjugated
Modification: Unmodified