Product Description

MLL Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA11671-50, RA11671-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: lysine methyltransferase 2A (KMT2A) Homo sapiens This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefS

Reactivity: Human

Host: Mouse

Applications: WB, IHC-p, IF(paraffin section), ELISA

Alternate Names: MLL, ALL1, CXXC7, HRX, HTRX, KMT2A, MLL1, TRX1, Histone-lysine N-methyltransferase MLL, ALL-1, CXXC-type zinc finger protein 7, Lysine N-methyltransferase 2A, KMT2A, Trithorax-like protein, Zinc finger protein HRX

Clonality: Monoclonal

Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

Storage: -20°C/1 year

Condition: Ascitic fluid containing 0.03% sodium azide, 0.5% BSA, 50% glycerol.

Human Gene ID: 4297

Research Use Only