Product Description

MLST8 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: AP1000-50, AP1000-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Subunit of both mTORC1 and mTORC2, which regμlates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimμlated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragμlator complex and the Rag GTPases. Activated mTORC1 up-regμlates protein synthesis by phosphorylating key regμlators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: G protein beta subunit like, G protein beta subunit-like, Gable, GBL, GBL protein, LST8, Mammalian lethal with SEC13 protein 8, MGC111011, mLST8, Protein GbetaL, Target of rapamycin complex subunit LST8, TORC subunit LST8,

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding Human MLST8.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MLST8 polyclonal antibody detects endogenous levels of MLST8 protein.

Molecular Weight: ~ 36 kDa

Pathway: Glutamine Metabolism, MTOR signaling,

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q9BVC4

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only