MMP-11 Polyclonal Antibody - BT-AP05474

MMP-11 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP05474-20, BT-AP05474-50, BT-AP05474-100

Citations, Manuals and MSDS Available upon request.

Background: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, Stromelysin-3 encoded by MMP11 is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix.

Research Areas: Cardiovascular

Target Protein: MMP11

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human, Mouse, Rat

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: MMP-11 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 54618

UniProt Accession: Human: P24347; Mouse: Q02853; Rat: Q499S5

Synonyms: MMP11; STMY3; Stromelysin-3; SL-3; ST3; Matrix metalloproteinase-11; MMP-11

GeneID: Human: 4320; Mouse: 17385; Rat: 25481

Research Use Only