Product Description

MMP-13 (L22) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS1231-50, BS1231-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The matrix metalloproteinases (MMP) are a family ofpeptidase enzymes responsible for the degradation of extracellμlar matrix components, including collagen, gelatin, fibroPVRL1, laminin and proteoglycan. Transcriptionof MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B(SEB). MMP catalysis requires both calcium and zinc.MMP-13 (also designated collagenase-3) is produced bybreast carcinomas and degrades collagen types I, II andIII. MMP-13 has wide substrate specificity, and its physiologic expression is limited to situations in which rapidand effective remodeling of collagenous ECM takesplace, such as fetal bone development and adμlt bone remodeling

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB, IHC, IF

Alternate Names: Collagenase 3, Matrix metalloproteinase-13 (MMP-13), MMP13

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: Synthetic peptide, corresponding to Human MMP-13.

Dilution: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MMP-13 (L22) polyclonal antibody detects endogenouslevels of ~55 kDa latent or the ~40 kDa active forms ofMMP-13 protein.

Molecular Weight: ~ 55, 40 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P45452

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only