MMP-13 Polyclonal Antibody - BT-AP05477

MMP-13 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP05477-20, BT-AP05477-50, BT-AP05477-100

Citations, Manuals and MSDS Available upon request.

Background: MMP13 encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Collagenase 3 in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.

Research Areas: Cardiovascular

Target Protein: MMP13

Applications: WB, IHC-p, IF, ELISA

Reactivity: Human

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: MMP-13 Antibody

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

Molecular Weight (Da): 53820

UniProt Accession: Human: P45452; Mouse: P33435

Synonyms: MMP13; Collagenase 3; Matrix metalloproteinase-13; MMP-13

GeneID: Human: 4322

Research Use Only