MMP-2 Mouse Monoclonal Antibody - RA10498

MMP-2 Mouse Monoclonal Antibody

Size: 50μL, 100μL

Catalogue Numbers: RA10498-50, RA10498-100

Citations, Manuals and MSDS Available upon request.

Background: matrix metallopeptidase 2 (MMP2) Homo sapiens This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Win

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Storage Instructions: -20°C/1 year

Applications: WB; IF/ICC/ICC

Species Cross-Reactivity: Transfected; Rat; Human

GeneID (Human): 4313

Protein MW (KDa): 72

SWISS: P08253

Source: Mouse

Research Use Only