Product Description

MMP13 (Cleaved-Tyr104) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27295-50, RA27295-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 4 calcium ions per subunit., disease:Defects in MMP13 are the cause of spondyloepimetaphyseal dysplasia type 2 (SEMD2) [MIM:602111]; also known as spondyloepimetaphyseal dysplasia type Missouri. SEMDs are a heterogeneous group of skeletal disorders characterized by defective growth and modeling of the spine and long bones. The SEMDs are distinguished from the spondylometaphyseal dysplasias and the spondyloepiphyseal dysplasias by the combined involvement of the epiphyses and metaphyses. The 3 disorders have malformations of the vertebrae in common., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., function:Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process., similarity:Belongs to the peptidase M10A family., similarity:Contains 4 hemopexin-like domains., tissue specificity:Seems to be specific to breast carcinomas.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Collagenase 3 (EC 3.4.24.-;Matrix metalloproteinase-13;MMP-13)

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 42 53

Protein Molecular Weight (kDa): 42 53

Storage: -20°C/1 year

Human Gene ID: 4322

Human SwissProt Number: P45452

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only