Product Description

MMP21 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60692-50, BS60692-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The matrix metalloproteinases (MMPs) are a family of peptidase enzymes responsible for the degradation of extracellμlar matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-21 is 569 amino acid residues in length and consists of a prodomain, catalytic domain, and haemopexin-like domain. It is the human orthologue for XMMP in X. laevis and CyMMP in C. pyrrhogaster. MMP-21 is expressed in various fetal and adμlt tissues. It a possible target gene of the Wnt pathway, and the expression of this protein is controlled by Pax and Notch transcription factors. MMP-21 may play an important role in embryogenesis, tissue development (particμlarly in the brain), tumor progression and possibly apoptosis.

Category: Primary Antibody

Reactivity: Human

Host: Rabbit

Applications: WB

Alternate Names: Matrix metalloproteinase-21, MMP-21

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human MMP21

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MMP21 polyclonal antibody detects endogenous levels of MMP21 protein.

Molecular Weight: ~ 65 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q8N119

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only