MMP26 Polyclonal Antibody
Catalogue Numbers: BS60573-50, BS60573-100
Sizes: 50µl, 100µl
Alternative Name: Matrix metalloproteinase-26; MMP-26; Endometase; Matrilysin-2; MMP26
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q9NRE1
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB
All Applications: WB: 1:500~1:1000
Background: Metalloproteinases (MMPs) are a family of proteins that are involved in the breakdown of the extracellular matrix during normal cellular events, including reproduction, tissue remodeling and embryonic development. MMP-26 (matrix metallopeptidase-26), also known as Endometase or Matrilysin-2, is a 261 amino acid metalloproteinase that is secreted as an inactive protein and is activated upon cleavage by extracellular proteinases. Expressed specifically in the placenta and uterus, MMP-26 hydrolyzes (and subsequently degrades) a variety of proteins such as Fibrinogen, Fibronectin, Vitronectin and collagen type IV (COL4). MMP-26 binds zinc and calcium as cofactors and, unlike other MMP family members, lacks a conserved C-terminal domain. MMP-26 is widely expressed in a number of malignant tumor lines where it is thought to play an important role in tissue remodeling events that are associated with carcinogenesis.
Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: MMP26 polyclonal antibody detects endogenous levels of MMP26 protein.
Bioworld Molecular Weight: ~ 29 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot (WB) analysis of MMP26 polyclonal antibody at 1:500 dilution
Lane 1: HEK293T whole cell lysate
Lane 2: Raw264.7 whole cell lysate
Lane 3: H9C2 whole cell lysate
Immunogen: A synthetic peptide corresponding to residues in Human MMP26
Conjugate: Unconjugated
Modification: Unmodified