Product Description

MMP8 (Cleaved-Leu101) Rabbit Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA27306-50, RA27306-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I., cofactor:Binds 2 zinc ions per subunit., cofactor:Binds 3 calcium ions per subunit., domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme., enzyme regulation:Cannot be activated without removal of the activation peptide., function:Can degrade fibrillar type I, II, and III collagens., similarity:Belongs to the peptidase M10A family., similarity:Contains 4 hemopexin-like domains., subcellular location:Stored in intracellular granules., tissue specificity:Neutrophils.,

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB, ELISA

Alternate Names: Neutrophil collagenase (EC 3.4.24.34;Matrix metalloproteinase-8;MMP-8;PMNL collagenase;PMNL-CL)

Clonality: Polyclonal

Dilution: WB 1:1000-2000 ELISA 1:5000-20000

Molecular Weight: 40 53

Protein Molecular Weight (kDa): 40 53

Storage: -20°C/1 year

Human Gene ID: 4317

Human SwissProt Number: P22894

Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Research Use Only