Product Description

MNX1/HLXB9 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS65681-50, BS65681-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: The HB9 homeobox transcription factor regμlates gene expression during embryonic development and also in specific adμlt tissues. HB9 gene mutations are implicated in Curriano syndrome, which is characterized by a triad consisting of a presacral tumor, sacral agenesis and anorectal malformation. In human bone marrow cells, HB9 expression directly correlates with CD34 expression. Furthermore, HB9 expression increases in CD34+ cells that are treated with IL-3 and granμlocyte macrophage-colony-stimμlating factor. Early in murine development, HB9 is expressed in pancreatic buds (dorsal and ventral) with subsequent expression in differentiating beta cells in the islets of Langerhans. The dorsal lobe of the pancreas fails to form in HB9(-) mice, the resμltant pancreas has smaller islets of Langerhans and less beta cells than normal pancreas. The HB9 gene is expressed in the human adμlt pancreas. In the developing vertebrate embryo, the HB9 gene plays an essential role in motor neuron differentiation. The motor columns of HB9(-) mice are disorganized, lacking phrenic and abducens nerves and exhibiting intercostal nerve defects.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit

Host: Rabbit

Applications: FCM

Alternate Names: HB9/HLXB9, HB 9, HB9, HLXB 9, HLXB9, Homeo box HB9, Homeobox HB9, Homeobox protein HB9, HOXHB9, MNX1, MNX1_HUMAN, Motor neuron and pancreas homeobox protein 1, Sacral agenesis autosomal dominant (Currarino triad), SCRA 1, SCRA1, SCRA1, HOXHB9.

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: KLH conjugated synthetic peptide derived from human HLXB9

Dilution: Flow-Cyt=1ug/Test

Purification: affinity purified by Protein A

Specificity: MNX1/HLXB9 Polyclonal Antibody detects endogenous levels of MNX1/HLXB9 protein.

Molecular Weight: 41kD

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P50219

Product: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Research Use Only