Product Description

MonoMethyl-UHRF1-K385 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS74109-50, BS74109-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regμlate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regμlating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regμlated in various cancers, and it is therefore considered to be a therapeutic target. Mμltiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: DB, WB, IHC

Alternate Names: UHRF1, ICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Methylated

Immunogen: A synthetic monomethylated peptide around K385 of human UHRF1(NP_001041666.1).

Dilution: DB, 1:500 - 1:2000 WB, 1:500 - 1:2000 IHC, 1:50 - 1:200

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: Methylated

Molecular Weight: 91kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q96T88

Product: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only