Product Description

MRCKG Polyclonal Antibody

Sizes: 50μL, 100μL

Catalogue Numbers: RA33372-50, RA33372-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: catalytic activity:ATP + a protein = ADP + a phosphoprotein., cofactor:Magnesium., enzyme regulation:Maintained in an inactive, closed conformation by an interaction between the kinase domain and the negative autoregulatory C-terminal coiled-coil region. Agonist binding to the phorbol ester binding site disrupts this, releasing the kinase domain to allow N-terminus-mediated dimerization and kinase activation by transautophosphorylation., function:May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 CNH domain., similarity:Contains 1 CRIB domain., similarity:Contains 1 PH domain., similarity:Contains 1 phorbol-ester/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., subcellular location:Concentrates at the leading edge of cells., subunit:Homodimer and homotetramer via the coiled coil regions. Interacts tightly with GTP-bound but not GDP-bound CDC42., tissue specificity:Expressed in heart and skeletal muscle.,

Reactivity: Human, Rat, Mouse

Host: Rabbit

Applications: WB, ELISA

Clonality: Polyclonal

Dilution: WB 1:500-2000 ELISA 1:5000-20000

Molecular Weight: 170

Protein Molecular Weight (kDa): 170

Storage: -20°C/1 year

Human Gene ID: 55561

Human SwissProt Number: Q6DT37

Condition: Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.

Research Use Only