Mre11 (Phospho-Ser676) Rabbit Polyclonal Antibody - BT-AP11362

Mre11 (Phospho-Ser676) Rabbit Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11362-20, BT-AP11362-50, BT-AP11362-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a nuclear protein involved in homologous recombination| telomere length maintenance| and DNA double-strand break repair. By itself| the protein has 3andapos; to 5andapos; exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3andapos; to 5andapos; exonuclease activities. In conjunction with a DNA ligase| this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Research Areas: Epigenetics and nuclear signaling

Target Protein: MRE11A

Applications: WB

Reactivity: Human, Rat, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Mre11

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: P49959; Mouse: Q61216; Rat: Q9JIM0

Synonyms: Mre11;Ser676; Double-strand break repair protein MRE11A; Meiotic recombination 11 homolog 1; MRE11 homolog 1; Meiotic recombination 11 homolog A; MRE11 homolog A

GeneID: Human: 4361; Mouse: 17535; Rat: 64046

Research Use Only