Mre11 (phospho-Ser676) Rabbit Polyclonal Antibody - RA27365

Mre11 (phospho-Ser676) Rabbit Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA27365-50, RA27365-100 Citations, Manuals and MSDS Available upon request. Background: MRE11 homolog, double strand break repair nuclease (MRE11) Homo sapiens This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: WB 1:1000-2000 Alternative Names: Double-strand break repair protein MRE11A (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A) Applications: WB Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 4361 Protein MW (KDa): 80 SWISS: P49959 Source: Rabbit Research Use Only