Mre11 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90878-50, BS90878-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: P49959(Human) Q61216(Mouse) Q9JIM0(Rat)
Host: Rabbit
Reactivity: Human, Mouse, Rat
Applications: WB, IHC
All Applications: WB:1:500-1:1,000
IHC:1:50-1:200
Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: Mre11 polyclonal antibody detects endogenous levels of Mre11 protein.
Bioworld Molecular Weight: 81 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: Western blot analysis of Mre11 on different cells lysates using anti-Mre11 antibody at 1/500 dilution.
Positive control: Line 1: 293T Line 2: Hela
, Immunohistochemical analysis of paraffin-embedded human breast cancer tissue using anti- Mre11 antibody. Counter stained with hematoxylin.
Alternative Name: MRE11 homolog 1, MRE11 homolog A, MRE11, AT like disease, Ataxia telangiectasia disorder like, ATLD, DNA recombination and repair protein, Double strand break repair protein MRE11A, Double-strand break repair protein MRE11A, endo/exonuclease Mre11, HNGS1, meiotic recombination (S. cerevisiae) 11 homolog A, Meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A (S. cerevisiae), Meiotic recombination 11 homolog A, MmMRE11A, Mre 11, MRE 11a, MRE 11b, MRE11 homolog 1, MRE11 homolog A, MRE11 meiotic recombination 11 homolog A (S. cerevisiae), MRE11 meiotic recombination 11 homolog A, MRE11, MRE11A, MRE11b, OTTHUMP00000236830, OTTHUMP00000236831, OTTHUMP00000236832, OTTHUMP00000236833,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified