MRP2 Polyclonal Antibody
Sizes: 50µl, 100µl
Catalogue Numbers: BS90880-50, BS90880-100
Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Swiss-Prot: Q92887(Human)
Host: Rabbit
Reactivity: Human
Applications: WB, ICC IHC FC
All Applications: WB:1:500-1:1,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
Background: Multi-drug resistance protein 2 (MRP2), also known as ABCC2, is an ATP binding cassette (ABC) transporter responsible for biliary excretion of xenobiotics, endobiotics, and their metabolites. Deficiency in ABCC2 results in the clinical disorder Dubin-Johnson syndrome. MRP2 is found to be expressed in a variety of human cancers, and is associated with resistance of tumor cells to various anticancer drugs including cisplatin. The predicted molecular weight of MRP2 is 174 kDa, while mature MRP2 usually has a slower migration around 190-250 kDa due to the glycosylation.
Purification and Purity: ProA affinity purified
Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: MRP2 polyclonal antibody detects endogenous levels of MRP2 protein.
Bioworld Molecular Weight: 174 kDa
Note: For research use only, not for use in diagnostic procedure.
Extra Notes: ICC staining MRP2 in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS., ICC staining MRP2 in 293T cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
Alternative Name: ABCC2, CMOAT, CMOAT1, CMRP, MRP2, ABC30, abcC2, ATP binding cassette sub family C (CFTR/MRP) member 2, ATP binding cassette subfamily C member 2, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, CMOAT, CMOAT1, cMRP, DJS, KIAA1010, MRP 2, MRP2, Multidrug resistance associated protein 2, Multidrug resistance-associated protein 2,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodified