Product Description

MRP3 (L1010) Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS3177-50, BS3177-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicμlar mμltispecific organic anion transporter) and MRP3, which are both conjugate export pumps ex- pressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the basolateral membrane where it also me- diates the transport of the organic anion S-(2, 4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Canalicμlar mμltispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Mμlti-specific organic anion transporter D, MOAT-D, Mμltidrug resistance-associated protein 3, ABCC3, CMOAT2, MLP2, MRP3

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: Synthetic peptide, corresponding to amino acids 981-1030 of Human MRP3.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MRP3 (L1010) polyclonal antibody detects endogenous levels of MRP3 protein.

Molecular Weight: ~ 260  kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: O15438

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only