MRTF-A (H11) Polyclonal Antibody-BS2342

MRTF-A (H11) Polyclonal Antibody

Catalogue Numbers:BS2342-50, BS2342-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q969V6

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: Serum response factor (SRF) is a transcription factor that binds the serum response element (SRE), a sequence that mediates the transient response of many cellular genes to growth stimulation. SRF regulates the transient response of several muscle genes in response to growth factors and recruits accessory myogenic factors to activate these muscle genes. SRF is required for the formation of vertebrate mesoderm leading to the origin of the cardiovascular system. Myocardin, in association with SRF in cardiac muscle cells, activates cardiac muscle promoters. Myocardin-related transcription factor A (MRTF-A), also known as MKL1, interacts with SRF and stimulates its transcriptional activity.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Bioworld Molecular Weight: ~ 99 kDa

Specificity: MRTF-A (H11) polyclonal antibody detects endogenous levels of MRTF-A protein.

Note: For research use only, not for use in diagnostic procedure.
Alternative Name: MKL/myocardin-like protein 1; Megakaryoblastic leukemia 1 protein; Megakaryocytic acute leukemia protein; Myocardin-related transcription factor A; MRTF-A; MKL1; KIAA1438; MAL

Immunogen: Synthetic peptide, corresponding to the N-terminal of Human MRTF-A.

Conjugate: Unconjugated

Modification: Unmodified