MSH6 / GTBP (E371) Polyclonal Antibody-BS2420

MSH6 / GTBP (E371) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS2420-50, BS2420-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P52701

Host: Rabbit

Reactivity: Human, Mouse

Applications: WB IHC IF

All Applications: WB: 1:500~1:1000
IHC: 1:50~1:200
IF: 1:50~1:200

Background: The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. A member of the mismatch repair family, GTBP (also designated MSH6), is a 160 kDa MSH2-related protein that binds to DNA containing G/T mismatches. Findings suggest that the mismatch-binding factor in human cells is composed of a heterodimer of GTBP and MSH2.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of GTBP (E371) pAb in paraffin-embedded human brain tissue.

Bioworld Molecular Weight: ~ 153 kDa

Specificity: GTBP (E371) polyclonal antibody detects endogenous levels of GTBP protein.

Alternative Name: DNA mismatch repair protein Msh6; hMSH6; G/T mismatch-binding protein; GTBP; GTMBP; MutS-alpha 160 kDa subunit; p160; MSH6; GTBP

Immunogen: Synthetic peptide, corresponding to amino acids 350-400 of Human MSH6.

Conjugate: Unconjugated

Modification: Unmodified