MSH6 Monoclonal Antibody - BT-MCA4287

MSH6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4287-50, BT-MCA4287-100

Citations, Manuals and MSDS Available upon request.

Background: Defects in MSH6 are a cause of hereditary non-polyposis colorectal cancer (HNPCC) (Lynch syndrome). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (crc) and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited colorectal cancer in the western world. MSH6 is central to mismatch DNA repair.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: MSH6

Reactivity: Human

Clonality: Monoclonal

Clone ID: 3A10H7

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MSH6

Immunogen: Purified recombinant fragment of MSH6 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

UniProt Accession: P52701

Synonyms: GTBP, HSAP, HNPCC5

GeneID: 2956

Research Use Only