MSH6 Monoclonal Antibody - BT-MCA4583

MSH6 Monoclonal Antibody

Sizes: 50μL, 100μL

Catalogue Number: BT-MCA4583-50, BT-MCA4583-100

Citations, Manuals and MSDS Available upon request.

Background: This gene encodes a protein similar to the MutS protein. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides, prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein of this gene combines with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene have been identified in individuals with hereditary nonpolyposis colon cancer (HNPCC) and endometrial cancer.

Research Areas: Epigenetics and Nuclear Signaling

Target Protein: MSH6

Applications: WB

Reactivity: Human

Clonality: Monoclonal

Clone ID: 5B11

Host: Mouse

Isotype: Mouse IgG1

Full Product Name: MSH6

Immunogen: Purified recombinant fragment of human MSH6 expressed in E. Coli.

Storage: 4°C|-20°C for long term storage

Formulation: Ascitic fluid containing 0.03% sodium azide.

Molecular Weight (Da): 160kDa

UniProt Accession: P52701

Synonyms: GTBP, HSAP, HNPCC5

GeneID: 2956

Research Use Only