Mst2 Polyclonal Antibody-BS90887

Mst2 Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90887-50, BS90887-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q13188(Human) Q9JI11(Mouse) O54748(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC, IP,

All Applications: WB:1:1,000-1:5,000
IHC:1:50-1:200

Background: Sterile-20 (Ste20) is a serine/threonine kinase in Saccharomyces cerevisiae that is involved in relaying signals from G protein-coupled receptors to cyto-solic MAP kinase cascades. Mammalian protein kinases that display sequence similarity to Ste20 are divided into two groups, the PAK subfamily and the GCK subfamily. The PAK subfamily members contain a C-terminal catalytic domain and an N-terminal regulatory domain with a p21Rac/Cdc42-binding site, and these kinases can activate both p38 MAPK and JNK. The GCK subfamily members contain a C-terminal regulatory domain and an N-terminal catalytic domain, and they have diverse roles in many pathways, including the activation of ERK, JNK, p38 MAPK, and caspase-3. The mammalian Ste20-like kinases (MST kinases), also known as Krs proteins, are members of the GCK subfamily. Ksr-1 (MST-2) and Ksr-2 (MST-1) are both direct substrates of caspase-3 that accelerate caspase-3 activation. MST-3 is ubiquitously expressed in mammalian tissue and can phosphorylate exogenous substrates as well as itself. MST-4 is highly expressed in placenta, thymus, and peripheral blood leukocytes, and it specifically activates ERK.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: Mst2 polyclonal antibody detects endogenous levels of Mst2 protein.

Bioworld Molecular Weight: 36/56 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Mst2 on different lysates using anti-Mst2 antibody at 1/1,000 dilution.
Positive control:
Lane 1: CRC
Lane 2: HCT116, Immunohistochemical analysis of paraffin-embedded mouse placenta tissue using anti-Mst2 antibody. Counter stained with hematoxylin.

Alternative Name: MST-2, STK3, KRS1, MST2, DKFZp686A2068, FLJ90748, KRS1, KRS2, Mammalian STE20 like protein kinase 1, Mammalian STE20 like protein kinase 2, MST 1, MST 2, MST1, MST2, Serine/threonine kinase 3 (STE20 homolog yeast), Serine/threonine kinase 3 (Ste20 yeast homolog), Serine/threonine kinase 3, Serine/threonine kinase 4, Serine/threonine protein kinase 3, Serine/threonine protein kinase 4, Serine/threonine protein kinase Krs 1, Serine/threonine protein kinase Krs 2, STE20 like kinase MST1, STE20 like kinase MST2, STK 3, STK 4, STK3, STK4, YSK3,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodified