Product Description

MT-ND2 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60187-50, BS60187-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: MT-ND2: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Defects in MT-ND2 are a cause of Leber hereditary optic neuropathy (LHON). LHON is a maternally inherited disease resμlting in acute or subacute loss of central vision, due to optic nerve dysfunction. Cardiac conduction defects and neurological defects have also been described in some patients. LHON resμlts from primary mitochondrial DNA mutations affecting the respiratory chain complexes. Defects in MT-ND2 may be associated with susceptibility to Alzheimer disease mitochondrial (AD-MT).

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: NADH-ubiquinone oxidoreductase chain 2, NADH dehydrogenase subunit 2, MTND2, NADH2, ND2

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodified

Immunogen: A synthetic peptide corresponding to residues in Human MT-ND2.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MT-ND2 polyclonal antibody detects endogenous levels of MT-ND2 protein.

Molecular Weight: ~ 39 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: P03891

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only