Product Description

MTHFD2 Monoclonal Antibody

Catalogue Numbers: MB66881-50, MB66881-100

Sizes: 50µl, 100µl

Product: Mouse IgG1 kappa. Liquid in PBS, pH 7.3, 30% glycerol, and 0.01% sodium azide.

Swiss-Prot: P13995

Host: Mouse

Reactivity: Human, Mouse

Applications: WB

All Applications: WB (1/1000 - 1/2000)

Background: MTHFD2 is a bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase involved in mitochondrial folate metabolism . MTHFD2 expression is developmentally regulated, as it is expressed in embryos but not in most adult tissues. Recent research studies have shown that MTHFD2 is consistently overexpressed in many cancer types and correlated with poor survival in breast cancer . Overexpression of MTHFD2 promotes cell proliferation while its depletion induces cell death in human cancer cells .

Purification and Purity: This antibody is purified through a protein G column.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of MTHFD2 protein.

Extra Notes: Western blot analysis of MTHFD2 expression in Hela (A), 293 (B), MOLT4 (C), mouse heart (D) whole cell lysates.

Bioworld Molecular Weight: ~ 40 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: NMDMC; Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial

Immunogen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human MTHFD2. The exact sequence is proprietary.

Conjugate: Unconjugated

Modification: Unmodified