Product Description

MUC6 Polyclonal Antibody

Sizes: 50μl, 100μl

Catalogue Numbers: BS60178-50, BS60178-100

Lead times: 1-2 weeks, if manufacturer has product in stock

Manufacturer/Ship Location: China

Background: Mucin 6 (also designated MUC 6 and gastricmucin) is a large glycoprotein that plays amajor role in the protection of the gastrointestinal tract. MUC6 carries GlcNAcα1→4Galβ→R structures, indicating thatα1, 4-N-acetylglucosaminyltransferase isimportant to the formation of the mucous glycoproteinsin vivo. Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileumand rightcolon. In gastriccancer, Mucin 6 has an altered expression. In normalstomach, Mucin 6 apomucin is associated with Lewistype 2, Mucin 6 is also expressed in gastric metaplasia, duodenum and pancreas. Mucin 6 is a secretory mucin, located in the deepermucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation. Mucin 6mRNA is expressed transientlyin the nephrogeniczone of the kidneyin the early mid-trimester of development, and Mucin 6 glycoprotein is expressed in the epithelium of ureteric buds and collecting ducts, but absent fromadμltkidney. Proliferating bile ductμlarcells express Mucin 6 apomucin in diseased liver, especially in chronicviral hepatitiswith active necroinflammation, suggesting that this secreted mucin acts as a cytoprotective agent and represents a phenotype of reactive biliary epithelium in chronicviral hepatitis.

Category: Primary Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Applications: WB

Alternate Names: Mucin-6, MUC-6, Gastric mucin-6, MUC6

Clonality: Polyclonal

Conjugate: Unconjugated

Modification: Unmodification

Immunogen: A synthetic peptide corresponding to residues in Human MUC6.

Dilution: WB: 1:500~1:1000

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Specificity: MUC6 polyclonal antibody detects endogenous levels of MUC6 protein.

Molecular Weight: ~ 270 kDa

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

SwissProt: Q6W4X9

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Research Use Only