Product Description

MuERVL-Gag Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90896-50, BS90896-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: V9H130

Host: Rabbit

Reactivity: Mouse

Applications: ICC

All Applications: ICC:1:200

Background: A large number of retrotransposons are expressed when the zygotic genome is first transcribed, including the endogenous retroviruses (ERVs), LINE-1 elements, and the non-autonomous SINE elements. At the 2C stage, MuERV-L/MERVL retrovirus-like elements are transiently de-repressed and produce 3% of the transcribed mRNAs. Following the 2C stage, MERVL-retroelement expression is silenced. The newly study discovered that this regulated pattern of MERVL expression overlapped with greater than one hundred 2C-specific genes that have co-opted regulatory elements from these foreign retroviruses to initiate their transcription.

Purification and Purity: Peptide affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: ICC staining MuERVL-Gag in mouse 3-cell stage embryo (red). The cells were incubated overnight at +4°C with MuERVL-Gag rabbit pAb at a 1/100 dilution (shown in red) and phalloidin (shown in green). Nuclear DNA was labelled with DAPI (shown in blue)

Bioworld Molecular Weight: 67 kDa

Specificity: MuERVL-Gag polyclonal antibody detects endogenous levels of MuERVL-Gag protein.

Alternative Name: Gag,

Immunogen: peptide

Conjugate: Unconjugated

Modification: Unmodified