MUL1 Polyclonal Antibody - BT-AP11587

MUL1 Polyclonal Antibody

Sizes: 20μL, 50μL, 100μL

Catalogue Numbers: BT-AP11587-20, BT-AP11587-50, BT-AP11587-100

Citations, Manuals and MSDS Available upon request.

Background: The zinc finger domain is required for E3 ligase activity.,E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,Contains 1 RING-type zinc finger.,subcellular location:Transported in mitochondrion-derived vesicles from the mitochondrion to the peroxisome.,subunit:Homooligomer. Interacts with MAP3K7/TAK1.,tissue specificity:Widely expressed with highest levels in the heart, skeletal muscle, placenta, kidney and liver. Barely detectable in colon and thymus.,

Research Areas: Cell biology; Metabolism

Target Protein: MUL1

Applications: WB, ELISA

Reactivity: Human, Mouse

Clonality: Polyclonal

Host: Rabbit

Isotype: IgG

Full Product Name: Mitochondrial ubiquitin ligase activator of NFKB 1

Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage: -20°C for 1 year

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration: 1 mg/ml

UniProt Accession: Human: Q969V5; Mouse: Q8VCM5

Synonyms: Mitochondrial ubiquitin ligase activator of NFKB 1;EC 6.3.2.-;E3 SUMO-protein ligase MUL1;E3 ubiquitin-protein ligase MUL1;Growth inhibition and death E3 ligase;Mitochondrial-anchored protein

GeneID: Human: 79594

Research Use Only