Product Description

Musculin (R167) Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS1886-50, BS1886-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: O60682

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: IHC

All Applications: IHC: 1:50~1:200

Background: MyoD-E or musculin-E heterodimers bind avidly to consensus E box motifs, which are functionally important elements in the promoter regions of many musclespecific terminal differentiation genes. MyoD complexes potently induce transcriptional activation, while musculin complexes bind adjacent to MyoD DNA-binding regions to represses MyoD activity, which then results in the delayed expression of muscle-specific genes. Musculin is highly expressed in undifferentiated and proliferating myoblasts in culture, and its expression is down regulated during myogenesis and at the onset of terminal differentiation.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Immunohistochemistry (IHC) analyzes of Musculin (R167) pAb in paraffin-embedded human lymph node tissue.

Bioworld Molecular Weight: ~ 22 kDa

Specificity: Musculin (R167) polyclonal antibody detects endogenous levels of Musculin protein.

Alternative Name: Musculin; Activated B-cell factor 1; ABF-1; Class A basic helix-loop-helix protein 22; bHLHa22; MSC; ABF1; BHLHA22

Immunogen: Synthetic peptide, corresponding to amino acids 141-190 of Human Musculin.

Conjugate: Unconjugated

Modification: Unmodified