Product Description

MVP Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS90898-50, BS90898-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q14764(Human) Q9EQK5(Mouse) Q62667(Rat)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, IHC

All Applications: WB:1:500-1:1,000
IHC:1:50-1:200

Background: Major vault protein (MVP), is overexpressed in various multidrug-resistant cancer cell lines and clinical samples. The promoter of MVP is TATA-less; contains an inverted CCAAT-box and a Sp1 site located near a p53 binding motif. MVP has two alternative splice variants, which differ from each other within the 5'-leader. The long-MVP isoform is ubiquitously expressed and represents an almost constant portion of the total MVP mRNA in many different normal tissues. MVP is the major component of the multimeric ribonucleoprotein complexes, with several copies of an untranslated RNA, which has been shown to transport along cytoskeletal-based cellular tracks. In conclusion, MVP protein mediates drug resistance, perhaps via a transport process.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: MVP polyclonal antibody detects endogenous levels of MVP protein.

Bioworld Molecular Weight: 99 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of MVP on A549 (1) and Hela (2) cell lysate using anti-MVP antibody at 1/1,000 dilution., Immunohistochemical analysis of paraffin-embedded human colon cancer tissue using anti-MVP antibody. Counter stained with hematoxylin.

Alternative Name: MVP, LRP, LRP, Lung resistance related protein, Lung resistance-related protein, Major vault protein, Major vault protein, rat, homolog of, MVP, MVP, testicular secretory protein Li 30, VAULT 1, VAULT1,

Immunogen: Recombinant protein

Conjugate: Unconjugated

Modification: Unmodified