MYLK (phospho Tyr464) Polyclonal Antibody - RA27520

MYLK (phospho Tyr464) Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA27520-50, RA27520-100 Citations, Manuals and MSDS Available upon request. Background: myosin light chain kinase (MYLK) Homo sapiens This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications. Alternative Names: MYLK; MLCK; MLCK1; MYLK1; Myosin light chain kinase; smooth muscle; MLCK; smMLCK; Kinase-related protein; KRP; Telokin Applications: IHC-p; IF (paraffin section) ; ELISA Species Cross-Reactivity: Human; Rat; Mouse GeneID (Human): 4638 SWISS: Q15746 Source: Rabbit Research Use Only